Chloride channel antagonists perturb growth and morphology of Neurospora crassa.
نویسندگان
چکیده
The chloride channel antagonists anthracene-9-carboxylic acid, ethacrynic acid and niflumic acid were found to be fungistatic and morphogenic when tested against the ascomycete Neurospora crassa. Potency increased with decreasing pH, suggesting that the protonated forms of the compounds were active. Niflumic acid produced the most pronounced growth aberrations which may reflect an ability to acidify the cytoplasm and block the plasma membrane anion channel of N. crassa.
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ورودعنوان ژورنال:
- FEMS microbiology letters
دوره 201 2 شماره
صفحات -
تاریخ انتشار 2001